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FLASH GENE

Symbol

MYO9B

contributors: shn/npt - updated : 17-06-2009

HGNC name	myosin IXB
HGNC id	7609

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 40 - 7640 isoform 1 229 2157 - Latiano (2008) variant 2 40 - 7652 isoform 2 229 2022 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     lowly   intestine large intestine     lowly Lymphoid/Immune lymph node       highly   spleen       highly   thymus       moderately Reproductive female system ovary     lowly   male system prostate     lowly   male system testis     lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic       highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Lymphoid/Immune lymphocyte

cell lineage	abundant in cells of myeloid origin
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an extension in its globular N terminal domain
	a large insertion in the ATP binding site
	a neck with four IQ calmodulin binding sites
	a tail containing a chimeric-like apposition of a zinc binding motif and a (Rho GAP) GTPase activating domain
	a myosin head-like domain
	a loop 2 in the Myo9b head domain implicated in the interaction with F-actin
	a C terminal globular domain

HOMOLOGY

interspecies	ortholog to Myo9b, Rattus norvegicus
	ortholog to MYO9B, Pan troglodytes
	ortholog to Myo9b, Mus musculus
	ortholog to myo9b, Danio rerio

Homologene

FAMILY

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus

basic FUNCTION	may have a role in actin-based processes in myeloid cells
	might play a G-protein-coupled regulatory and/or transport function in membrane traffic
	is a processive actin-based motor
	actin-based motor molecules with ATPase activity, may be involved in the remodeling of the actin cytoskeleton
	involved in the early mucosal events preceding the well-understood inflammatory response

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

other,

calcium

protein	F-actin, Calmodulin 1
	brefeldin A-inhibited guanine nucleotide exchange protein 1 (BIG1)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to celiac disease (see CDIG7)

Variant & Polymorphism other	variant in intron 28, increasing the risk of celiac disease

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS