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FLASH GENE
Symbol MYO9B contributors: shn/npt - updated : 17-06-2009
HGNC name myosin IXB
HGNC id 7609
Location 19p13.11      Physical location : 17.186.590 - 17.324.103
Synonym name
  • MYO9B variant protein
  • unconventional myosin-9b
  • celiac disease 4
  • MYOSIN, RAT, HOMOLOG OF; MYR5
    • Synonym symbol(s) MYR5
    DNA
    TYPE functioning gene
    STRUCTURE 111.58 kb     39 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D19S899 - D19S593 - MYO9B - D19S410 - D19S429 - cen
    Authors Bähler (97),Hoffman (97),Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    40 - 7640 229 2157 - Latiano (2008)
    40 - 7652 229 2022 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  lowly
     intestinelarge intestine  lowly
    Lymphoid/Immunelymph node   highly
     spleen   highly
     thymus   moderately
    Reproductivefemale systemovary  lowly
     male systemprostate  lowly
     male systemtestis  lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoietic   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/Immunelymphocyte
    cell lineage abundant in cells of myeloid origin
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an extension in its globular N terminal domain
  • a large insertion in the ATP binding site
  • a neck with four IQ calmodulin binding sites
  • a tail containing a chimeric-like apposition of a zinc binding motif and a (Rho GAP) GTPase activating domain
  • a myosin head-like domain
  • a loop 2 in the Myo9b head domain implicated in the interaction with F-actin
  • a C terminal globular domain
    • HOMOLOGY
    interspecies ortholog to Myo9b, Rattus norvegicus
    ortholog to MYO9B, Pan troglodytes
    ortholog to Myo9b, Mus musculus
    ortholog to myo9b, Danio rerio
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • may have a role in actin-based processes in myeloid cells
  • might play a G-protein-coupled regulatory and/or transport function in membrane traffic
  • is a processive actin-based motor
  • actin-based motor molecules with ATPase activity, may be involved in the remodeling of the actin cytoskeleton
  • involved in the early mucosal events preceding the well-understood inflammatory response
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other, calcium
    protein
  • F-actin, Calmodulin 1
  • brefeldin A-inhibited guanine nucleotide exchange protein 1 (BIG1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to celiac disease (see CDIG7)
    Variant & Polymorphism other variant in intron 28, increasing the risk of celiac disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS