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FLASH GENE
Symbol HOXC9 contributors: mct - updated : 27-11-2010
HGNC name homeo box C9
HGNC id 5130
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text expressed throughout the E9.5 forelimb bud
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix, DNA binding domain
HOMOLOGY
interspecies homolog to murine Hox-3.2
homolog to Drosophila abd-B
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • involved in mouse posterior limb patterning
  • has an essential role in organizing the motor system through global repressive activities
  • required for the generation of thoracic motor columns, and in its absence, neurons acquire the fates of limb-innervating populations
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between the recombinant homeodomain (HD) of HOXC9 and MH1 domain of SMAD4
    • cell & other
    REGULATION
    inhibited by SMAD4 (SMAD4 inhibits HOXC9 transcription activity)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS