| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
| gain of function
|
|
coactivated by HOXA9 in myeloid leukemias, in infant acute lymphoblastic leukemia |
| tumoral
|
|
|
| gain of function
|
|
in neuroblastoma cell lines and with HOXB3 in acute myeloid leukemia |
| tumoral
|
| amplification
|
|
|
|
or overexpressed in neuroblastoma, erythroleukemia or medulloblastoma |
| tumoral
|
|
| --over
|
|
|
represses myeloid-specific gene transcription, thereby contributing to differentiation block in leukemogenesis |
| tumoral
|
|
| --over
|
|
extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis  |
| constitutional
|
|
|
| loss of function
|
|
results in cardiac anomalies that resemble those caused by PBX mutations |
| tumoral
|
|
| --over
|
|
|
of HOXA9 and HOXA10 and their essential cofactor MEIS1 in cells with the t(4;11) chromosome translocation and MLL-AF4 in acute leukemia |
