| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
| amplification
|
|
| |
strongly selected for during tumour progression as a mechanism to suppress the TP53 response in RB1-deficient retinal cells | | tumoral
|
|
| --over
|
| |
in malignant glioma escaping TP53 dependent growth control | | tumoral
|
|
| --low
|
|
downregulation of MDM4 expression associates with cisplatin resistance in ovarian cancers  | | constitutional
|
| deletion
|
|
| |
induces multipolar mitotic spindle formation and the loss of chromosomes from hyperploid TP53-null cells | | tumoral
|
| amplification
|
|
| |
in breast carcinomas, colon carcinomas, lung carcinomas, and a smaller percentage of gliomas | | constitutional
|
|
| --over
|
| |
in fibroblast-like synoviocyte, may contribute to the hyperplasia phenotype of rheumatoid arthritis synovial tissues | | tumoral
|
|
| --over
|
| |
in retinoblastoma | | constitutional
| germinal mutation
|
|
|
| |
in a family with features suggestive of dyskeratosis congenita, e.g., bone marrow hypocellularity, short telomeres, tongue squamous cell carcinoma, and acute myeloid leukemia | |
