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FLASH GENE

Symbol

HOXC8

contributors: mct - updated : 28-01-2009

HGNC name	homeo box C8
HGNC id	5129

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies

homolog to murine Hox-3.1

Homologene

FAMILY

homeodomain protein family

CATEGORY

transcription factor , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in mouse anterior and posterior patterning and innervation of the limb
	playing a role in the acquisition of invasive and metastatic prostate cancer
	may play a role in the regulation of cartilage differentiation
	acting as a transcriptional regulator in a variety of developmental processes during embryogenesis (Kong 2008)
	blocks the AR-dependent recruitment of the steroid receptor coactivators steroid receptor NCOA3)

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

complexing with PBX1 (PBX1-HOXC8 heterocomplex may lead to androgen-independent growth in prostate cancer) (Kikugawa 2006)

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate cancer with loss of differentiation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS