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FLASH GENE
Symbol HOXC8 contributors: mct - updated : 28-01-2009
HGNC name homeo box C8
HGNC id 5129
Location 12q13.13      Physical location : 54.402.889 - 54.406.543
Synonym name homeo box C8(3A)
Synonym symbol(s) HOX3, HOX3A
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
STRUCTURE 3.65 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure
  • a regulatory motif (GUCE-GTF2IRD1 Upstream Control Element)
  • MAPPING cloned Y linked N status provisional
    Map cen - D12S881 - D12S1507 - HOXC8 - D12S325 - D12S1961 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2290 - 242 - Kikugawa (2006)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    helix-turn-helix, DNA binding domain
    HOMOLOGY
    interspecies homolog to murine Hox-3.1
    Homologene
    FAMILY homeodomain protein family
    CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in mouse anterior and posterior patterning and innervation of the limb
  • playing a role in the acquisition of invasive and metastatic prostate cancer
  • may play a role in the regulation of cartilage differentiation
  • acting as a transcriptional regulator in a variety of developmental processes during embryogenesis (Kong 2008)
  • blocks the AR-dependent recruitment of the steroid receptor coactivators steroid receptor NCOA3)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component complexing with PBX1 (PBX1-HOXC8 heterocomplex may lead to androgen-independent growth in prostate cancer) (Kikugawa 2006)
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer with loss of differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS