basic FUNCTION
| regulator of intracellular cholesterol trafficking,from late endosome/lysosome to caveolin 1 and 2 compartment such as the trans Golgi network and plasma membrane caveolae |
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putative transmembrane efflux pump |
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may be facilitate endocytic transport, lysosomal cholesterol efflux and fatty acid efflux |
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having functions in regulating lysosomal amine content  |
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may facilitate the transport of cholesterol directly between two compartments, late endosomes/lysosomes and distinct regions of the endoplasmic reticulum  |
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regulates the transport of cholesterol from late endosomes/lysosomes to other compartments responsible for maintaining intracellular cholesterol homeostasis  |
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regulates the transport of cholesterol from late endosomes/lysosomes to other compartments responsible for maintaining intracellular cholesterol homeostasis  |
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with NPC2 can function independently of one another in the egress of certain membrane-impermeable lysosomal cargo  |
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functions independently of NPC2 in late endosome/lysosome retrograde fusion that leads to the creation of hybrid organelles  |
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soluble NPC2 and membrane-bound NPC1 are cholesterol-binding lysosomal proteins required for export of lipoprotein-derived cholesterol from lysosomes  |
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action for NPC1 and NPC2 in mediating cholesterol efflux  |
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both NPC1 and NPC2 proteins participate in endosomal/lysosomal processing of both sphingolipids and cholesterol  |
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function of NPC1, NPC2 within lysosomes are linked closely  |
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importance of the interaction between NPC1 and NPC2 proteins to accomplish cholesterol delivery from lysosomes into the cytoplasm  |
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required for cholesterol efflux from late endosomes and lysosomes  |
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possible role of NPC1 in platelet function and formation  |
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may play a role in adipocyte processes underlying obesity  |
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