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FLASH GENE
Symbol AZGP1 contributors: mct/pgu - updated : 26-08-2010
HGNC name alpha-2-glycoprotein 1, zinc-binding
HGNC id 910
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Connectiveadipose   
cells
SystemCellPubmedSpeciesStageRna symbol
 adipocyte
cell lineage
cell lines
fluid/secretion plasma, seminal plasma, urine, saliva, sweat
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Azgp1
homolog to C.elegans F52C6.9
Homologene
FAMILY
  • MHC class I family
    • CATEGORY secretory , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • stimulating lipid degradation in adipocytes
  • causing the extensive fat losses associated with some advanced cancers
  • plays an important role in the mobilization and utilization of stored lipids, and may play an important role in the regulation of adipose mass in obesity and cachexia
  • lipid-mobilizing factor involved in regulating lipid metabolism and adiposity
  • tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-beta-mediated ERK signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid degradation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • binding to polyunsaturated fatty acids
    • REGULATION
    Other
  • its expression is regulated by glucocorticoids
    • ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in pancreatic ductal adenocarcinoma
    tumoral     --low  
    in prostate carcinoma with risk of metastatic progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS