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FLASH GENE

Symbol

AZGP1

contributors: mct/pgu - updated : 26-08-2010

HGNC name	alpha-2-glycoprotein 1, zinc-binding
HGNC id	910

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001185 4 - 1247 NP_001176 34.3 298 - 1993 830756

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Connective adipose

cells

System Cell Pubmed Species Stage Rna symbol   adipocyte

cell lineage
cell lines
fluid/secretion	plasma, seminal plasma, urine, saliva, sweat

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Azgp1
	homolog to C.elegans F52C6.9

Homologene

FAMILY

MHC class I family

CATEGORY

secretory , tumor suppressor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	stimulating lipid degradation in adipocytes
	causing the extensive fat losses associated with some advanced cancers
	plays an important role in the mobilization and utilization of stored lipids, and may play an important role in the regulation of adipose mass in obesity and cachexia
	lipid-mobilizing factor involved in regulating lipid metabolism and adiposity
	tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-beta-mediated ERK signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

lipid degradation

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

binding to polyunsaturated fatty acids

REGULATION

Other

its expression is regulated by glucocorticoids

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in pancreatic ductal adenocarcinoma tumoral     --low   in prostate carcinoma with risk of metastatic progression

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS