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FLASH GENE

Symbol

SPOCK1

contributors: mct/npt - updated : 07-07-2008

HGNC name	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
HGNC id	11251

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	524.00 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see IRF1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed SPOCK1 10 - 4841 49 439 - Prenzel (2006)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear       highly Nervous brain       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	CWCV and Kazal-like domains proteoglycan
	osteonectin (SPARC)-like domain
	thyroglobuline type 1 repeat

HOMOLOGY

interspecies

homolog to murine Spock1

Homologene

FAMILY

testican family proteins

CATEGORY

adhesion , regulatory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	multifunctional matricellular protein involved in cell-matrix interactions and might be involved in tumor pathogenesis and progression
	may have a function related to protease inhibition in the blood

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

text	control of cell proliferation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   overexpression is significantly more frequent in pancreatic cancer than cancer of the papilla of Vater

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS