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FLASH GENE

Symbol

TUBA8

contributors: mct/npt - updated : 03-12-2009

HGNC name	tubulin, alpha 8
HGNC id	12410

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain forebrain cerebral cortex   highly Reproductive male system testis       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

Text	widely expressed in developing neural structures (Abdollahi 2009)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine Tuba8

Homologene

FAMILY

tubulin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	major constituent of microtubules
	may be playing a role in regulating mammalian brain development (Abdollahi 2009)
	participates in microtubule assembly in mammalian cells (Abdollahi 2009)
	implicated in a specific aspect of cerebral cortical development (Abdollahi 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PMGOH

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS