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FLASH GENE
Symbol CCR8 contributors: mct/npt - updated : 28-10-2011
HGNC name chemokine (C-C motif) receptor 8
HGNC id 1609
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Cmkbr8
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
    • CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may play an important role in vessel wall pathology
  • mast cell-derived CCL1- and CCR8-expressing CD4(+) effector T lymphocytes play an essential role in orchestrating lung mucosal inflammatory responses
  • in the complex microenvironment in the allergic lung both eosinophils as well as T cells can be potentially recruited to the site of inflammation in response to CCL1 through CCR8
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CCR8/CCL1 interaction may play a role in type 1 diabetes through macrophage recruitment and activation
  • CCR8 ligands are allotropic, binding to distinct sites within CCR8 and the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand
  • have only one major mammalian ligand, namely CCL1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS