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FLASH GENE

Symbol

CCR8

contributors: mct/npt - updated : 28-10-2011

HGNC name	chemokine (C-C motif) receptor 8
HGNC id	1609

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	3.97 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005201 2 - 1487 40.7 355 - 2006 17023422

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen           thymus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Blood/Hematopoietic NK cell Lymphoid/Immune T cell Homo sapiens

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Cmkbr8

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

receptor G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may play an important role in vessel wall pathology
	mast cell-derived CCL1- and CCR8-expressing CD4(+) effector T lymphocytes play an essential role in orchestrating lung mucosal inflammatory responses
	in the complex microenvironment in the allergic lung both eosinophils as well as T cells can be potentially recruited to the site of inflammation in response to CCL1 through CCR8

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	CCR8/CCL1 interaction may play a role in type 1 diabetes through macrophage recruitment and activation
	CCR8 ligands are allotropic, binding to distinct sites within CCR8 and the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand
	have only one major mammalian ligand, namely CCL1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS