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FLASH GENE
Symbol PRMT1 contributors: mct/npt/pgu - updated : 27-06-2015
HGNC name protein arginine methyltransferase 1
HGNC id 5187
Location 19q13.33      Physical location : 50.180.495 - 50.191.704
Synonym name
  • interferon receptor 1-bound protein-4
  • HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae)
  • Synonym symbol(s) HCP1, HMT1, ANM1, IR1B4, HRMT1L2
    EC.number 2.1.1.25
    DNA
    TYPE anonymous DNA segment
    SPECIAL FEATURE arranged in tandem, opposite orientation
    STRUCTURE 11.21 kb     11 Exon(s)
    MAPPING cloned Y linked   status provisional
    Map cen - D19S827 - [D19S420 - D19S832 - D19S835 - D19S720 - D19S218 ] - qter
    Text [PRMT1 ]
    RNA
    TRANSCRIPTS type messenger
    text can produce up to seven protein isoforms, all varying in their N-terminal domain
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1505 - 347 - 2008 20719712
  • a functional nuclear export sequence
  • isoform 2
  • 11 splicing 1386 - 371 - 2008 20719712
  • isoform 1
  • 10 splicing 1332 - 353 - 2008 20719712
  • isoform 3
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousbrainhindbraincerebellum  
    Reproductivefemale systembreast   
     female systemuterus  highly
     male systemprostate   
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • N terminal hydrophobic region-SAM (sterile alpha motif) binding domain
  • mono polymer homomer , oligo
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae MMT1like 2
    homolog to murine Prmt1 (99.4pc)
    homolog to rattus Hrmt1l2 (99.4pc)
    intraspecies homolog to IR1B4
    Homologene
    FAMILY
  • protein arginine N-methyltransferase family
  • CATEGORY enzyme , transcription factor , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text
  • only a fraction of PRMT1 is located in the nucleus, but the protein is predominantly cytoplasmic
  • colocalize in nuclear speckles, a sub-nuclear compartment enriched in small nuclear ribonucleoproteins and splicing factors
  • basic FUNCTION
  • arginine methyltransferase transferring a methyl group from S adenosylmethionine to the guanidino group nitrogen atoms of specific proteins
  • methylation of histone H4 involved in transcriptional regulation
  • plays a role in nuclear receptor-mediated chromatin remodeling and RNA transactions
  • catalyzing arginine methylation for the post-translational protein modification
  • cooperating with CARM1 in gene regulation
  • represses a subset of IFNgamma-inducible STAT1 target genes in a methyltransferase-dependent manner
  • methylating RUNX1 and serving as a transcriptional coactivator for RUNX1
  • may control telomere length and stability through TERF2 methylation
  • dysregulation of PRMT1 and PRMT6 can be involved in human carcinogenesis
  • PRMT1 and PRMT5 methylate Arg-296 within ASH2L
  • responsible for most cellular arginine methylation activity and can work independently or in collaboration with other PRMTs
  • involved in arginine methylation, which participates in the nuclear-cytoplasmic shuttling of FUS, particularly of ALS6-associated mutants, and thus contributes to the toxic gain of function conferred by these disease-causing mutations
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • S adenosylmethionine dependent
  • protein
  • binding to hnRNP (heterogeneous nuclear ribonucleoproteins)
  • methylating FMRP
  • interact with CNOT7 and colocalize in nuclear speckles, a sub-nuclear compartment enriched in small nuclear ribonucleoproteins and splicing factors
  • crucial negative regulator of STAT1 activation that controls PIAS1-mediated repression by arginine methylation
  • methylating HNRNPK and so regulating its functions
  • TAF15 interactor and the major PRMT responsible for its methylation
  • directly interacts with and methylates the 378th arginine residue of Axin
  • transcriptional corepressor of IFN-induced STAT1 target genes that cooperates with PIAS1
  • PRMT1 serves as the major methyltransferase in cells by forming higher-order oligomers with itself, PRMT2, and possibly other PRMTs
  • PRMT1 interacts with RUNX1-RUNX1T1 to promote its transcriptional activation and progenitor cell proliferative potential
  • GSK3A, and PRMT1 cooperate to orchestrate a series of posttranslational modifications on the Intermediate filament (IF) -anchoring protein desmoplakin (DSP) that play an essential role in coordinating cytoskeletal dynamics and cellular adhesion
  • ATXN2L associates with the protein arginine-N-methyltransferase 1 (PRMT1)
  • PRMT1 is a direct interaction partner of UBAP2L
  • PRMT1 is overexpressed in human melanoma, and may regulate tumor growth and metastasis via targeting ALCAM
  • potent stress granules (SG)-nucleating protein G3BP1 is methylated by protein arginine methyltransferase 1 and 5 (PRMT1 and PRMT5)
  • TRIM48 facilitates oxidative stress-induced MAP3K5 activation and cell death through ubiquitination-dependent degradation of PRMT1
  • cell & other
    REGULATION
    Other trapped by unmethylated substrates such as core histones and heterogeneous nuclear ribonucleoprotein proteins until it has executed the methylation reaction
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
  • in breast cancer
  • the relative balance of PRMT1 isoforms is altered
  • constitutional     --low  
    reduced PRMT1 protein levels in the aganglionosis segments of HSCR patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • can be a useful marker for Hirschsprung disease
  • Therapy target
    ANIMAL & CELL MODELS