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FLASH GENE

Symbol

GGT1

contributors: npt - updated : 24-08-2007

HGNC name	gamma-glutamyltransferase 1
HGNC id	4250

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	all transcripts encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005265 - splicing 2431 NP_005256 61.4 569 - Bulle (1987), Han (2007) also called variant 1 five exons in the 5' UTR NM_013430 - splicing 2381 NP_038347 61.4 569 placenta Bulle (1987), Han (2007) also called variant 3 six exons in the 5'UTR NM_001032364 - splicing 2376 NP_001027536 61.4 569 - Bulle (1987), Han (2007) also called variant 4 seven exons in the 5'UTR NM_001032365 - - 2393 NP_001027537 - 569 - Han (2007) also called variant 5

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon sigmoid   Respiratory lung         Skin/Tegument skin         Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

precursor cleaved, a heavy and a light chain (351 and 189AA)

isoforms

Precursor

HOMOLOGY

interspecies

homolog to murine Ggtp

intraspecies

homolog to GGT2

Homologene

FAMILY

gamma-glutamyltransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	type 2 membrane protein

basic FUNCTION

transfer of the glutamyl moiety of glutamine to a variety of AAs and adipocytes acceptors

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GGT1

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS