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FLASH GENE
Symbol SRP72 contributors: mct - updated : 09-05-2012
HGNC name signal recognition particle 72kDa
HGNC id 11303
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine tetratricopeptide-like repeats (TPRs) poised to interact with other SRP or ribosomal proteins were predicted in the N-terminal region
  • a minimal region capable of forming a stable complex with an SRP RNA fragment encompassed AAs 545 to 585 of the full-length SRP72 and contained a lysine-rich cluster (KKKKKKKKGK) at postions 552 to 561 as well as a conserved Pfam motif
  • a C terminal domain of interaction with SRP68
    • HOMOLOGY
    interspecies homolog to C.elegans F08D12.1
    ortholog to murine Srp72
    homolog to rattus Rn.36055
    homolog to Xenopus Xl.5137
    homolog to zebrafish Dr.9066
    Homologene
    FAMILY
  • SRP72 family
    • CATEGORY antigen , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • playing a crucial role in targeting secretory proteins to rough endoplasmic reticulum membrane
  • participating in the elongation arrest function
  • implicated in binding to the SRP receptor and promoting the directional translocation of newly translated proteins bearing a signal sequence into the lumen of the ER
  • has at least two functions that are individually redundant and the conformation of the complex is critical for efficient completion of its biogenesis
  • component of the signal recognition particle (SRP), which is responsible for arresting translation of nascent proteins that are destined for the cell membrane or extracellular secretion and transferring them to the endoplasmic reticulum (ER) for correct trafficking
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • S domain made of a unique SRP RNA sequence and SRP9, SRP14, SRP19, SRP54, SRP68, SRP72
  • component of a ribonucleoprotein complex
  • SRP68 and SRP72 form a heterodimer
    • INTERACTION
    DNA
    RNA binding to 7S RNA in presence of SRP68
    small molecule
    protein
  • binding to SRPR
  • SRP68-SRP72 interaction remained stable at elevated salt concentrations and engaged approximately 150 amino acids from the N-terminal region of SRP72
    • cell & other
  • binding directly to the docking protein in the endoplasmic reticulum membrane
    • REGULATION
    repressed by inhibitors of the MAPK pathway that down-regulate the expression of SRP72 autoantigen in Jurkat cells
    Other cleaved during apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s) BMFS1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS