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FLASH GENE
Symbol DIO1 contributors: - updated : 24-08-2007
HGNC name deiodinase, iodothyronine, type I
HGNC id 2883
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a selenocysteine at position 382
    • HOMOLOGY
    interspecies homolog to rat Dio1 (88p100)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in inappropriate thyroid-stimulating hormone secretion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    thyroid
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in benign and malignant thyroid tumors
    tumoral     --low  
    in nearly all papillary thyroid carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target useful as potential targets for thyroid tumor treatment
    ANIMAL & CELL MODELS