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FLASH GENE

Symbol

DIO1

contributors: - updated : 24-08-2007

HGNC name	deiodinase, iodothyronine, type I
HGNC id	2883

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	like-sequence
STRUCTURE	16.00 kb     3 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 1876 - 249 - de Jong variant 2 - - 1684 - 185 - de Jong variant 3 - - 1732 - 201 - de Jong variant 4 - - 1676 - 161 - de Jong

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Endocrine thyroid       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a selenocysteine at position 382

HOMOLOGY

interspecies

homolog to rat Dio1 (88p100)

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth

basic FUNCTION

involved in inappropriate thyroid-stimulating hormone secretion

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

thyroid

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in benign and malignant thyroid tumors tumoral     --low   in nearly all papillary thyroid carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	useful as potential targets for thyroid tumor treatment

ANIMAL & CELL MODELS