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FLASH GENE
Symbol DIO1 contributors: - updated : 24-08-2007
HGNC name deiodinase, iodothyronine, type I
HGNC id 2883
Location 1p33-p32      Physical location : 54.359.860 - 54.376.758
Synonym name
  • type-I 5'deiodinase
  • thyroxine deiodinase type I (selenoprotein)
    • Synonym symbol(s) 5DI, MGC130050, MGC130051, TXDI1
    EC.number 1.97.1.10
    DNA
    TYPE like-sequence
    STRUCTURE 16.00 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1876 - 249 - de Jong
    - - 1684 - 185 - de Jong
    - - 1732 - 201 - de Jong
    - - 1676 - 161 - de Jong
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinethyroid   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a selenocysteine at position 382
    • HOMOLOGY
    interspecies homolog to rat Dio1 (88p100)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in inappropriate thyroid-stimulating hormone secretion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    thyroid
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in benign and malignant thyroid tumors
    tumoral     --low  
    in nearly all papillary thyroid carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target useful as potential targets for thyroid tumor treatment
    ANIMAL & CELL MODELS