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FLASH GENE
Symbol MAGEA9 contributors: mct - updated : 23-03-2009
HGNC name melanoma antigen family A, 9
HGNC id 6807
Location Xq28      Physical location : 148.663.313 - 148.869.394
Synonym name
  • MAGE-9 antigen
  • melanoma-associated antigen 9
  • cancer/testis antigen family 1, member 9
  • Synonym symbol(s) MAGE9, MAG9, CT1.9, MGC8421, MAGEA9B
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 5.81 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1824 35 315 - Rogner (1995)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte Homo sapiens
    cell lineage
    cell lines many tumor cell lines (melanoma, lung, breast), esophageal tumor
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MAGE domain
  • HOMOLOGY
    intraspecies homolog to MAGEA4/MAGEA11
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may play a role in embryonal development and tumor transformation or aspects of tumor progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in superficial bladder cancer
    tumoral     --over  
    in renal cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerurinarybladder
    relevant target for immunotherapy or chemoimmunotherapy because its expression can be induced by chemotherapeutic drugs, in bladder cancer
    cancerurinarykidney
    as well as RAGE may well provide suitable targets for immunotherapy of renal cell carcinoma
    ANIMAL & CELL MODELS