Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in breast cancer, melanoma, advanced gastric carcinomas and hepatocellular carcinomas, squamous cell carcinoma of head and neck, malignant myeloma | constitutional
|  
|  
| --low
|  
|
results in Tp53 transcriptional induction, also through reciprocal histone acetylation and methylation modifications (Zhu 2008) | tumoral
|  
|  
| --over
|  
|
by promoter hypomethylation up-regulates its expression in colorectal carcinomas as well as in gastric cancers and might play a significant role in the development and progression of colorectal carcinomas (Kim 2006) | tumoral
|  
|  
| --over
|  
|
GPC3, MAGE1A and MAGEA3 were increased with advanced tumor stage, size, and nodule numbers in Hepatocellular Carcinoma | tumoral
|  
|  
| --over
|  
|
is associated with worse overall survival in undifferentiated pleomorphic sarcoma/myxofibrosarcoma (UPS/MFS) | tumoral
|  
|  
| --over
|  
|
in bladder cancer and especially in tumours of high stage and grade | |