| protein
| androgen receptor NH(2)-terminal FXXLF motif (alpha-helical region) |
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is an AR coregulator that specifically binds the AR NH(2)-terminal FXXLF motif and modulates the AR NH(2)- and carboxyl-terminal N/C interaction to increase AR transcriptional activity  |
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MAGEA11 links N-terminal domains of AR and EP300 to promote transcriptional synergy through a cadre of FXXLF-related interacting motifs |
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coregulator effects of MAGEA11 on the AR N and C-terminal interaction amplify the androgen-dependent transcriptional response to EP300 required for normal human male sex development in utero |
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increases AR transcriptional activity by forming a molecular bridge between transcriptionally active AR dimers |
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interacts with the AR N-terminal FXXLF motif, increases AR-(1–660) activity directly, and increases the activity of wild-type AR in the absence or presence of androgen |
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MAGEA11 interaction with RBL1 was associated with transcriptional repression in cells with low MAGEA11 and transcriptional activation in cells with higher MAGEA11 |
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notable correlation between MAGEA5 and MAGEA11 and lower efficacy of EGFR tyrosine kinase inhibitors (TKI) in Head and Neck Cancer |
