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FLASH GENE
Symbol MAGEA10 contributors: npt/ - updated : 28-03-2006
HGNC name melanoma antigen family A, 10
HGNC id 6797
Location Xq28      Physical location : 151.302.906 - 151.307.025
Synonym name
  • MAGE-10 antigen
  • cancer/testis antigen family 1, member 10
  • Synonym symbol(s) MAGE10, MGC10599, CT1.10
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 4.12 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1610 40 369 - Lin
  • 5 exons
  • encoding the same protein than variant 2
  • - splicing 1519 40 369 - Lin, Strausberg
  • 4 exons
  • lacking exon 3
  • differing in the 5' UTR compared to variant 1
  • encoding the same protein than variant 1
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  moderately
    Endocrineadrenal gland   moderately
    Reproductivefemale systemplacenta  highly
     male systemtestis   
    Skin/Tegumentskin   predominantly
    cell lineage
    cell lines melanoma cell lines, head and neck squamous cell carcinoma, lung and breast cacinoma cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MAGE domain
  • HOMOLOGY
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may play a role in embryonal development and tumor transformation, or aspects of tumor progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS