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FLASH GENE

Symbol

MAGEA10

contributors: npt/ - updated : 28-03-2006

HGNC name	melanoma antigen family A, 10
HGNC id	6797

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xq28      Physical location : 151.302.906 - 151.307.025
Synonym name	MAGE-10 antigen
	cancer/testis antigen family 1, member 10
Synonym symbol(s)	MAGE10, MGC10599, CT1.10

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	4.12 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 1610 40 369 - Lin 5 exons encoding the same protein than variant 2 variant 2 - splicing 1519 40 369 - Lin, Strausberg 4 exons lacking exon 3 differing in the 5' UTR compared to variant 1 encoding the same protein than variant 1

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     moderately Endocrine adrenal gland       moderately Reproductive female system placenta     highly   male system testis       Skin/Tegument skin       predominantly

cell lineage
cell lines	melanoma cell lines, head and neck squamous cell carcinoma, lung and breast cacinoma cell lines
fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a MAGE domain

HOMOLOGY

Homologene

FAMILY

MAGE family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

may play a role in embryonal development and tumor transformation, or aspects of tumor progression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS