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FLASH GENE

Symbol

RRP1

contributors: mct - updated : 28-08-2014

HGNC name	ribosomal RNA processing 1 homolog (S. cerevisiae)
HGNC id	18785

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	14.57 kb     13 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - PDXK -CSTB - RRP1 - TMEM1 - PWP2H - C21orf33 - PGA1 - C21orf2 - PFKL PFKL - TRPC7 - UBE2G2 - qter
Authors	Wiltshire (99)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003683 13 - 1820 NP_003674 52 461 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Digestive liver       moderately Endocrine pancreas       moderately Nervous brain       moderately Respiratory lung       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	ubiquitously in fetus

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to C.elegans C47E12.7
	homolog to yeast S.cerevisiae YD78
	ortholog to murine Nnp1
	homolog to Drosophila Nnp-1

Homologene

FAMILY

RRP1 family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	playing a critical role in the generation of 28S rRNA
	FBL and RRP1 are associated with pre-ribosome particles distinctly different from each other

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

C1QBP is a new rRNA maturation factor involved in the remodeling from pre-90S particles to pre-40S and pre-60S particles that requires the exchange of FBL for RRP1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS