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FLASH GENE

Symbol

RRP1

contributors: mct - updated : 28-08-2014

HGNC name	ribosomal RNA processing 1 homolog (S. cerevisiae)
HGNC id	18785

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	21q22.3      Physical location : 45.209.417 - 45.223.983
Synonym name	novel nuclear protein 1,homolog to C. elegans C47E12.7 protein and to S. cerevisae YD78 protein
	DNA segment on chromosome 21 (unique) 2056 expressed sequence
	Nnp1 homolog, nucleolar protein (Drosophila)
	RRP1-like protein
Synonym symbol(s)	NNP1, NOP52, NNP-1, D21S2056E, RRP1A

DNA

TYPE	functioning gene
STRUCTURE	14.57 kb     13 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - PDXK -CSTB - RRP1 - TMEM1 - PWP2H - C21orf33 - PGA1 - C21orf2 - PFKL PFKL - TRPC7 - UBE2G2 - qter
Authors	Wiltshire (99)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003683 13 - 1820 NP_003674 52 461 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Digestive liver       moderately Endocrine pancreas       moderately Nervous brain       moderately Respiratory lung       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	ubiquitously in fetus

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to C.elegans C47E12.7
	homolog to yeast S.cerevisiae YD78
	ortholog to murine Nnp1
	homolog to Drosophila Nnp-1

Homologene

FAMILY

RRP1 family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	playing a critical role in the generation of 28S rRNA
	FBL and RRP1 are associated with pre-ribosome particles distinctly different from each other

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

C1QBP is a new rRNA maturation factor involved in the remodeling from pre-90S particles to pre-40S and pre-60S particles that requires the exchange of FBL for RRP1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS