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FLASH GENE
Symbol DCTN6 contributors: mct - updated : 06-11-2017
HGNC name dynactin 6 (p27)
HGNC id 16964
Location 8p12      Physical location : 30.013.812 - 30.041.059
Synonym name
  • putative adhesin protein, 20.7kDa, in the Werner critical region
  • likely ortholog of mouse dynactin 6
  • novel RGD-containing protein
  • dynactin subunit p27
  • protein WS-3
  • Synonym symbol(s) WRN3, WS3, WS-3, p27
    DNA
    TYPE functioning gene
    STRUCTURE 27.34 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - DCTN6 - D8S1055 - TUBBP1 - RBPMS /D8S339 - GTF2E2 - cen
    Authors Ichikawa (97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1126 - 190 - 2013 23455152
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselsaorta   
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Epithelial    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one RGD motif in the N terminal region
  • contain the isoleucine-patch motif and adopt the left-handed parallel beta-helix fold
  • an unusual left-handed beta-helix domain, with the phosphorylation site located within a disordered, C-terminal segment
  • HOMOLOGY
    interspecies homolog to murine Ws3
    Homologene
    FAMILY
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,chromatin/chromosome,kinetochore
    basic FUNCTION
  • playing a role in mitochondrial biogenesis
  • DCTN5, DCTN6 are peripheral components that can be removed without any obvious impact on dynactin integrity and dynactin lacking these subunits shows reduced membrane binding
  • part of protein complex required for the function of cytoplasmic dynein, a microtubule (MT)-based motor
  • plays a previously undescribed regulatory role in the spindle assembly checkpoint by recruiting PLK1 to kinetochores and facilitating phosphorylation of important downstream targets
  • CELLULAR PROCESS nucleotide, genomic integrity
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    results in impaired early and recycling endosome movement, but late endosome movement is unaffected, and mitotic spindles appear normal
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS