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FLASH GENE

Symbol

IL1R2

contributors: mct/npt - updated : 29-05-2010

HGNC name	interleukin 1 receptor, type II
HGNC id	5994

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   appears to be a protective mechanism in hearing homeostasis (Vambutas 2009) constitutional     --over   results in changes in cell morphology, actin rearrangement, and promoted cell migration, through activation of the pre-interleukin 1alpha pathway (Chang 2009)

Susceptibility

to ankylosing spondylitis

Variant & Polymorphism

Candidate gene	may be a specific biomarker for Autoimmune Inner Ear Disease (AIED) (Vambutas 2009)
Marker
Therapy target	can neutralize IL1 beta and counteract its effect on endometrial stromal cells, and may provide a new clinical strategy for the treatment of endometriosis (Hou 2008)

ANIMAL & CELL MODELS