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FLASH GENE

Symbol

IL1R2

contributors: mct/npt - updated : 29-05-2010

HGNC name	interleukin 1 receptor, type II
HGNC id	5994

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	36.58 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	regulated by alternate splicing, and the major inhibitory function is attributed to the full-length IL1R2 (Vambutas 2009)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004633 9 - 1484 NP_004624 - 398 - Symons (1995), Vambutas (2009) NM_173343 9 - 1436 NP_775465 - 398 - Symons (1995), Vambutas (2009)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a ligand binding domain
	three Ig-like domain
	a single transmembrane domain
	a short cytoplasmic domain lacking the Drosophila Toll signal (see IL1R1)

isoforms

Precursor

with a transmembrane isoform and an alternatively spliced soluble form (secreted)

HOMOLOGY

Homologene

FAMILY

interleukin-1 receptor family

CATEGORY

signaling cytokine , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	transmembrane protein

basic FUNCTION

molecular decoy that traps interleukin-1beta (IL1B) and does not initiate subsequent signaling events, thereby suppressing an inflammatory response (Vambutas 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

by dexamethasone (Vambutas 2009)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   appears to be a protective mechanism in hearing homeostasis (Vambutas 2009) constitutional     --over   results in changes in cell morphology, actin rearrangement, and promoted cell migration, through activation of the pre-interleukin 1alpha pathway (Chang 2009)

Susceptibility

to ankylosing spondylitis

Variant & Polymorphism

Candidate gene	may be a specific biomarker for Autoimmune Inner Ear Disease (AIED) (Vambutas 2009)
Marker
Therapy target	can neutralize IL1 beta and counteract its effect on endometrial stromal cells, and may provide a new clinical strategy for the treatment of endometriosis (Hou 2008)

ANIMAL & CELL MODELS