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FLASH GENE

Symbol

BCL8

contributors: - updated : 28-02-2007

HGNC name	B-cell CLL/lymphoma 8
HGNC id	1007

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Endocrine pancreas       lowly Reproductive male system testis         male system prostate       Urinary kidney       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

HOMOLOGY

interspecies

homolog to C.elegans F10.f2.1

intraspecies

homolog to LRBA

Homologene

FAMILY

BCL8 family

CATEGORY

enzyme , protooncogene

SUBCELLULAR LOCALIZATION

basic FUNCTION

presumptive protein kinase A anchoring function

CELLULAR PROCESS	cell life, antiapoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     diffuse large-cell lymphomas (DLCL)with recurrent translocations affecting the chromosomal region 15q11-13 and various other partners

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS