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FLASH GENE

Symbol

ATXN3

contributors: mct/pgu - updated : 27-06-2018

HGNC name	ataxin 3
HGNC id	7106

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MJD

Susceptibility

Variant & Polymorphism other	no evidence for an instability predisposing haplotype due to the stretch of polyglutamine

Candidate gene	for therapeutic by ribosome-interacting drugs (to fight the toxicity of polyalanine-frameshifted peptides)
Marker
Therapy target
	System Type Disorder Pubmed neurology ataxia   potential therapeutic role of ataxin-3 activity for polyglutamine disorders neurology ataxia   target for therapeutic by ribosome-interacting drugs (to fight the toxicity of polyalanine-frameshifted peptides) cancer     targeting ATXN3 may be a promising strategy to radio-sensitise BRCA-deficient cancers

ANIMAL & CELL MODELS