Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

BNC1

contributors: mct - updated : 07-04-2021

HGNC name	basonuclin 1
HGNC id	1081

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

POF16

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by hypermethylation in renal cell carcinoma tumoral     --low   by hypermethylation in renal cell carcinoma tumoral     --low   of BNC1 and BNC2 is associated with genetic or epigenetic regulation in hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	methylation status of ADAMTS1 and BNC1 in cfDNA shows promise for detecting pancreatic cancer during the early stages when curative resection of the tumor is still possible
Therapy target

ANIMAL & CELL MODELS

	Bnc1-null male mice were sub-fertile, losing germ cells progressively with age
	male mice carrying the truncation mutation exhibited progressively fertility loss and testicular premature aging