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FLASH GENE
Symbol KPNA2 contributors: mct - updated : 29-12-2018
HGNC name karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
HGNC id 6395
Location 17q24.2      Physical location : 66.031.847 - 66.042.969
Synonym name
  • RAG cohort 1
  • importin alpha 1
  • recombination-activating gene cohort 1
  • karyopherin subunit alpha-2
  • pendulin
    • Synonym symbol(s) RCH1, SRP1ALPHA, IMA2, QIP2, IPOA1, SRP1
    DNA
    TYPE functioning gene
    STRUCTURE 11.10 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2011 57.7 529 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervous    highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoligodendrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic Hydrophobic
    STRUCTURE
    motifs/domains
  • 10 ARM repeats
  • one IBB domain
  • a highly basic N terminus and an acidic C terminus
    • HOMOLOGY
    interspecies homolog to rattus Kpna2 (94.7pc)
    homolog to murine Kpna2 (94.5pc)
    intraspecies paralog to QIP1
    Homologene
    FAMILY
  • importin alpha protein family
    • CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text cytoplasmic face of the nuclear pore complex (NPL) translocated to nucleus after loading protein and complexing with importin beta
    basic FUNCTION
  • may be involved in nuclear import of proteins
  • may play a role in V(D)J recombination
  • functioning in nuclear protein import as an adapter protein for nuclear receptor KPNB1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text nuclear
    PATHWAY
    metabolism
    signaling
    a component
  • component of the NLS import receptor including an heterodimer of importin alpha and beta
  • found in a complex with CSE1L/XPO2 and RAN
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • recognizing the nuclear localization signal of nuclear proteins (NLS),such as PLAG1, DNA helicase Q1
  • interacting with POU5F1 (Li 2008)
  • TPR import was mediated by the most abundant import receptor, KPNA2, which binds the bipartite NLS in TPR with nanomolar affinity
  • nuclear import of RELA mainly relies on the canonical KPNA2/KPNB1 pathway
  • EI24 can bind specifically to KPNA2/KPNB1 to impede their normal role in nuclear import, shedding new light on the cellular functions of EI24 and its tumor suppressor role
  • interactions observed between TNRC6A and KPNA2
  • USP22 promoted nuclear translocation of IRF3 by deubiquitianting and stabilizing KPNA2 after viral infection
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS