Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

LTBP2

contributors: mct/npt - updated : 25-05-2018

HGNC name	latent transforming growth factor beta binding protein 2
HGNC id	6715

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

GLC3D , MSPKA , WMS3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in Marfan syndrome tumoral     --over   in pancreatic ductal adenocarcinoma (PDAC) tissue

Susceptibility

to BMD variation (bone mineral density) in trochanter and total hip

Variant & Polymorphism other	strong genetic association between LTBP2 gene locus and total hip BMD variation

Candidate gene
Marker	LTBP2 powerfully predicted early pulmonary death (LTBP2 levels were significantly higher in patients dying from pulmonary causes)
	serum LTBP2 levels might act as a promising biomarker in heart failure with reduced ejection fraction (HFREF)
	is a novel biomarker for the diagnosis of Pancreatic cancer
Therapy target
	System Type Disorder Pubmed cancer endocrine pancreas may be a potential target for PDAC clinical therapy

ANIMAL & CELL MODELS