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FLASH GENE
Symbol SYT5 contributors: mct - updated : 14-12-2009
HGNC name synaptotagmin V
HGNC id 11513
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an intravesicular N terminal domain
  • a single transmembrane (TM) region
  • two protein kinase C-homologous repeats (Ca2+ binding domains C2)
  • a conserved WHXL motif in the C terminus
    • mono polymer homomer , heteromer , complex
    HOMOLOGY
    interspecies ortholog to murine Syt5
    ortholog to C.elegans f31e8.2
    ortholog to rattus Syt5
    Homologene
    FAMILY
  • synaptotagmin family
    • CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    basic FUNCTION
  • calcium sensor for transmitter release at the central synapse, involved in exocytosis and endocytosis
  • SYT3, SYT5, SYT6, and SYT10 exhibit similar Ca2+-dependent phospholipid- and SNARE-binding properties as SYT1, although with a higher apparent Ca2+-affinity
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS nervous system , exocytosis transport , endocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • multifunctional intrinsic membrane protein of synaptic vesicles of neurons and chromaffin granules
  • SYT10 belongs to a group of Ca2+-binding synaptotagmins that includes SYT3, SYT5, and SYT6, and that differs from the group containing SYT1
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS