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FLASH GENE

Symbol

SYT5

contributors: mct - updated : 14-12-2009

HGNC name	synaptotagmin V
HGNC id	11513

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	7.25 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003180 9 - 1853 NP_003171 - 386 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an intravesicular N terminal domain
	a single transmembrane (TM) region
	two protein kinase C-homologous repeats (Ca2+ binding domains C2)
	a conserved WHXL motif in the C terminus

mono polymer

homomer , heteromer , complex

HOMOLOGY

interspecies	ortholog to murine Syt5
	ortholog to C.elegans f31e8.2
	ortholog to rattus Syt5

Homologene

FAMILY

synaptotagmin family

CATEGORY

structural protein , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,granule
	intracellular,cytoplasm,cytosolic,vesicle
	intracellular,nucleus

basic FUNCTION	calcium sensor for transmitter release at the central synapse, involved in exocytosis and endocytosis
	SYT3, SYT5, SYT6, and SYT10 exhibit similar Ca2+-dependent phospholipid- and SNARE-binding properties as SYT1, although with a higher apparent Ca2+-affinity

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

nervous system , exocytosis transport , endocytosis transport

PATHWAY

metabolism

signaling

a component	multifunctional intrinsic membrane protein of synaptic vesicles of neurons and chromaffin granules
	SYT10 belongs to a group of Ca2+-binding synaptotagmins that includes SYT3, SYT5, and SYT6, and that differs from the group containing SYT1

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS