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FLASH GENE

Symbol

LAT2

contributors: mct - updated : 08-01-2016

HGNC name	linker for activation of T cells family, member 2
HGNC id	12749

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032464 14 - 2199 NP_115853 26.2 243 - 2002 12486104 NM_032463 14 splicing 2129 NP_115852 26.2 243 - 2002 12486104 partial exon 2 NM_014146 13 splicing 2010 NP_054865 26.2 243 - 2002 12486104 lacking exon 2

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart         Digestive liver         Endocrine pancreas         Nervous brain       highly Homo sapiens Respiratory lung       highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Lymphoid/Immune dendritic cell Homo sapiens Lymphoid/Immune natural killer Nervous glia Homo sapiens not specific mast cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a short extracellular domain
	a transmembrane domain
	a juxtamembrane potential palmitoylation site used by LAT for localization in lipid rafts and tyrosine phosphorylation

HOMOLOGY

interspecies

homolog to murine Wbscr5

intraspecies

homolog to RNA binding proteins

Homologene

FAMILY

CATEGORY

adaptor , DNA associated

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
text	lipid rafts

basic FUNCTION	may be involved in FCER1-mediated signaling in mast cells
	may also be involved in BCR-mediated signaling in B-cells and FCGR1-mediated signaling in myeloid cells
	LAT and the linker for activation of B cells (LAB/NTAL/LAT2) are integral proteins in receptor coupling to downstream events
	is a critical, LAT-independent regulator of TREM2 signaling and macrophage development capable of controlling subsequent inflammatory responses
	playing a possible role in normal and malignant hematopoiesis
	participates in signalosome assembly in hematopoietic cells
	crucial role in signaling, via RHOA, to mast cell cytoskeleton
	transmembrane adaptor protein that functions in immunoreceptor-mediated signaling
	in contrast to its role in immunoreceptor-mediated signaling, function in LPS-mediated signaling pathway did not depend on its tyrosine phosphorylation (
	role of LAT2 during erythroid and myeloid differentiation of normal human CD34+ hematopoietic cells
	multiple regulatory roles of TAL2 in gene expression and mast cell physiology

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

linking BCR engagement to dowstream signaling pathway

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with GRB2
	target gene of AML1/ETO (RUNX1/RUNX1T1)
	interacting with SOS1, GAB1, CBL
	regulates FCER1A-mediated signaling at multiple steps and by different mechanisms
	link between LAT2 and CTNNB1 nuclear accumulation in dendritic cells that facilitates IFNG responses during anti-fungal immunity
	RUNX1T1 controls proliferation and the neurotoxic effect of microglia by epigenetically regulating CDK4 and LAT2 via its interaction with HDACs

cell & other

REGULATION

Other

phosphorylated by SYK

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     included in the Williams-Beuren commonly deleted region constitutional     --low   by silencing RNA oligonucleotides in mast cells (HuMCs) resulted in a reduction of both KIT- and FCER1A-mediated degranulation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS