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FLASH GENE
Symbol LAT2 contributors: mct - updated : 08-01-2016
HGNC name linker for activation of T cells family, member 2
HGNC id 12749
Location 7q11.23      Physical location : 73.624.086 - 73.644.163
Synonym name
  • linker for activation of B cells
  • Williams-Beuren syndrome chromosome region 5
  • membrane-associated adapter molecule
  • non-T-cell activation linker
  • Williams-Beuren syndrome chromosome region 15
    • Synonym symbol(s) HSPC046, WSCR5, WBSCR15, LAB, NTAL, WBSCR5,
    DNA
    TYPE functioning gene
    STRUCTURE 20.44 kb     14 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2199 26.2 243 - 2002 12486104
    14 splicing 2129 26.2 243 - 2002 12486104
    partial exon 2
    13 splicing 2010 26.2 243 - 2002 12486104
    lacking exon 2
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain   highly Homo sapiens
    Respiratorylung   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/Immunedendritic cell Homo sapiens
    Lymphoid/Immunenatural killer
    Nervousglia Homo sapiens
    not specificmast cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short extracellular domain
  • a transmembrane domain
  • a juxtamembrane potential palmitoylation site used by LAT for localization in lipid rafts and tyrosine phosphorylation
    • HOMOLOGY
    interspecies homolog to murine Wbscr5
    intraspecies homolog to RNA binding proteins
    Homologene
    FAMILY
    CATEGORY adaptor , DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text lipid rafts
    basic FUNCTION
  • may be involved in FCER1-mediated signaling in mast cells
  • may also be involved in BCR-mediated signaling in B-cells and FCGR1-mediated signaling in myeloid cells
  • LAT and the linker for activation of B cells (LAB/NTAL/LAT2) are integral proteins in receptor coupling to downstream events
  • is a critical, LAT-independent regulator of TREM2 signaling and macrophage development capable of controlling subsequent inflammatory responses
  • playing a possible role in normal and malignant hematopoiesis
  • participates in signalosome assembly in hematopoietic cells
  • crucial role in signaling, via RHOA, to mast cell cytoskeleton
  • transmembrane adaptor protein that functions in immunoreceptor-mediated signaling
  • in contrast to its role in immunoreceptor-mediated signaling, function in LPS-mediated signaling pathway did not depend on its tyrosine phosphorylation (
  • role of LAT2 during erythroid and myeloid differentiation of normal human CD34+ hematopoietic cells
  • multiple regulatory roles of TAL2 in gene expression and mast cell physiology
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    linking BCR engagement to dowstream signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GRB2
  • target gene of AML1/ETO (RUNX1/RUNX1T1)
  • interacting with SOS1, GAB1, CBL
  • regulates FCER1A-mediated signaling at multiple steps and by different mechanisms
  • link between LAT2 and CTNNB1 nuclear accumulation in dendritic cells that facilitates IFNG responses during anti-fungal immunity
  • RUNX1T1 controls proliferation and the neurotoxic effect of microglia by epigenetically regulating CDK4 and LAT2 via its interaction with HDACs
    • cell & other
    REGULATION
    Other phosphorylated by SYK
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    included in the Williams-Beuren commonly deleted region
    constitutional     --low  
    by silencing RNA oligonucleotides in mast cells (HuMCs) resulted in a reduction of both KIT- and FCER1A-mediated degranulation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS