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FLASH GENE

Symbol

LPAL2

contributors: mct/npt - updated : 08-06-2009

HGNC name	lipoprotein, Lp(a)-like 2
HGNC id	21210

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	part of the cluster SLC22A3-LPAL2-LPA
STRUCTURE	44.32 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	Variants 1 and 2 encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 10 - 2042 isoform 1 14.75 132 - Tregouet (2009) variant 2 10 - 1968 isoform 2 14.75 132 - Tregouet (2009)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland         Reproductive female system uterus cervix     Respiratory respiratory tract trachea

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

single kringle domain

conjugated

HemoP

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme , unknown/unspecified

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

unknown

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to coronary artery disease

Variant & Polymorphism SNP	four SNPs overlapping the SLC22A3-LPAL2-LPA gene cluster associated to risk of coronary artery disease (Tregouet 2009)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS