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FLASH GENE

Symbol

GSC2

contributors: mct - updated : 11-03-2011

HGNC name	goosecoid homeobox 2
HGNC id	4613

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     in Di George syndrome constitutional         loss of GSC2 and DGCR14 affects the regulation of hippocampal theta and rapid eye movement sleep, possibly contributing to the psychiatric symptoms frequently seen in patients who have 22q11 syndrome

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Gscl&
	8722;/&
	8722; mice have apparently normal anatomy and connections of the interpeduncular nucleus, but they exhibited a reduced total time spent in REM sleep and fewer rapid eye movement sleep (REM) episodes