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FLASH GENE

Symbol

COPA

contributors: mct/npt - updated : 20-08-2015

HGNC name	coatomer protein complex, subunit alpha
HGNC id	2230

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly Hearing/Equilibrium ear       highly Reproductive female system breast mammary gland   highly   male system testis     highly Respiratory respiratory tract trachea     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six WD-40 repeat motifs in the N terminal region

HOMOLOGY

interspecies

homolog to yeast S.cerevisiae alpha subunit of coatomer protein complex

Homologene

FAMILY

CATEGORY

structural protein , transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic,vesicle
text	typically Golgi associated, in neuronal cells COPA localizes to lamellipodia and growth cones and moves within the axon, with a subset of these granules traveling together with SMN1

basic FUNCTION	involved in the transport between the endoplasmic reticulum and Golgi
	stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone
	inhibit pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility
	SLC4A4 and the trafficking regulator gene COPA, plays an important role in early endosome maturation
	COPA and SLC4A4 are required for cellular entry of arginine-rich peptides

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

constituent of the coat of the non-clathrin-coated vesicles

INTERACTION

DNA

RNA

small molecule

protein

SMN1-binding partner, implicating this protein complex in normal SMN1 function, and this interaction serves an important function in the growth and maintenance of motor neuron processes and may play a significant role in the pathogenesis of SMA

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to syndrome of autoimmunity characterized by high-titer autoantibodies, inflammatory arthritis and interstitial lung disease

Variant & Polymorphism other	COPA variants impair binding to proteins targeted for retrograde Golgi-to-ER transport and is associated to syndrome of autoimmunity characterized by high-titer autoantibodies, inflammatory arthritis and interstitial lung disease

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS