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FLASH GENE
Symbol COPA contributors: mct/npt - updated : 20-08-2015
HGNC name coatomer protein complex, subunit alpha
HGNC id 2230
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Hearing/Equilibriumear   highly
Reproductivefemale systembreastmammary gland highly
 male systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six WD-40 repeat motifs in the N terminal region
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae alpha subunit of coatomer protein complex
    Homologene
    FAMILY
    CATEGORY structural protein , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • typically Golgi associated, in neuronal cells COPA localizes to lamellipodia and growth cones and moves within the axon, with a subset of these granules traveling together with SMN1
  • basic FUNCTION
  • involved in the transport between the endoplasmic reticulum and Golgi
  • stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone
  • inhibit pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility
  • SLC4A4 and the trafficking regulator gene COPA, plays an important role in early endosome maturation
  • COPA and SLC4A4 are required for cellular entry of arginine-rich peptides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the coat of the non-clathrin-coated vesicles
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SMN1-binding partner, implicating this protein complex in normal SMN1 function, and this interaction serves an important function in the growth and maintenance of motor neuron processes and may play a significant role in the pathogenesis of SMA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to syndrome of autoimmunity characterized by high-titer autoantibodies, inflammatory arthritis and interstitial lung disease
    Variant & Polymorphism other
  • COPA variants impair binding to proteins targeted for retrograde Golgi-to-ER transport and is associated to syndrome of autoimmunity characterized by high-titer autoantibodies, inflammatory arthritis and interstitial lung disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS