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FLASH GENE

Symbol

LTBR

contributors: SGE/npt - updated : 31-05-2010

HGNC name	lymphotoxin beta receptor (TNFR superfamily, member 3)
HGNC id	6718

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	constitutively inducing NF-KappaB activation and it may be associated with autonomous growth of melanoma cells (Dhawan 2008)
Marker
Therapy target

ANIMAL & CELL MODELS

engagment of Ltbr by Tnfsf14 is essential for both intestinal inflammation and hyperserum IgA syndrome in a murine model that spontaneously develops T cell-mediated intestinal inflammation (Wang 2004)