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FLASH GENE

Symbol

LTBR

contributors: SGE/npt - updated : 31-05-2010

HGNC name	lymphotoxin beta receptor (TNFR superfamily, member 3)
HGNC id	6718

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p13.31      Physical location : 6.493.356 - 6.500.732
Synonym name	TNFR superfamily, member 3
	tumor necrosis factor C receptor
	tumor necrosis factor receptor 2-related protein
Synonym symbol(s)	TNFRRP, TNFRSF3, CD18, D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR2-RP

DNA

TYPE	functioning gene
STRUCTURE	7.38 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002342 10 - 2136 NP_002333 - 435 - Crowe (1994)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   stomach       highly Nervous brain         Reproductive male system prostate       Urinary bladder       highly

cells

System Cell Pubmed Species Stage Rna symbol   epithelial cell Blood/Hematopoietic leukocyte Respiratory alveolar macrophage

cell lineage	myeloid lineages but not on T and B cells
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	extracytoplasmic cysteine-rich pseudorepeats
	a small cytoplasmic domain with the serine/threonine kinase but lacking the DEATH domain
	four TNFR-CYS repeats

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

tumor necrosis factor receptor TNFR superfamily

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	type 1 transmembrane protein

basic FUNCTION	specifically binding to the lymphotoxin membrane form and thus playing a role in the development and organization of lymphoid tissues and transformed cells
	promoting apoptosis via TRAF3 and TRAF5
	is required for liver regeneration, hepatitis and hepatic lipid metabolism (Tumanov 2007)

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

self-associating

INTERACTION

DNA

RNA

small molecule

protein	interacting with TRAF2 and TNFSF14 (TRAF2, an important effector molecule of TNF signaling, plays a critical, nonredundant role in TNFSF14-LTBR signaling)
	interacts with HCV core protein
	receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFSF14
	interacting with TRAF3, TRAF4, TRAF5
	ZMYND11 abrogates LTBR function through a protein-protein interaction

cell & other

REGULATION

Other

negatively regulated by TRAF3 (Bista 2010)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	constitutively inducing NF-KappaB activation and it may be associated with autonomous growth of melanoma cells (Dhawan 2008)
Marker
Therapy target

ANIMAL & CELL MODELS

engagment of Ltbr by Tnfsf14 is essential for both intestinal inflammation and hyperserum IgA syndrome in a murine model that spontaneously develops T cell-mediated intestinal inflammation (Wang 2004)