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FLASH GENE

Symbol

OPRM1

contributors: mct/npt - updated : 12-10-2015

HGNC name	opioid receptor, mu 1
HGNC id	8156

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

heroin/cocaine dependence to idiopathic generalized epilepsy or absence epilepsy to drug and alcohol dependence

Variant & Polymorphism other	G118 allele increases the risk of idiopathic generalized epilepsy
	SNP increasing the risk of drug and alcohol dependence
	polymorphisms that may explain the variability seen in the clinical response to opiates, both from an analgesic and polymorphisms in OPRM1 that may explain the variability seen in the clinical response to opiates, both from an analgesic and alcohol and substance use disorders (ASUD) stand-point (Ravindranathana 2009)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous pain   dissociation of OPRM1 from OPRD1 in the cell membrane is a potential strategy to improve opioid analgesic therapies

ANIMAL & CELL MODELS

Mor-1 KO mice with a disruption of exon 1 are unresponsive to morphine