basic FUNCTION
| inducing chromatin condensation followed by internucleosomal DNA fragmentation |
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with STK3, are activated in mitosis and catalyze the mitotic phosphorylation of MOBKL1A/MOBKL1B |
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serine/threonine protein kinase that is activated in response to a variety of apoptotic stimuli and causes apoptosis when over-expressed in mammalian cells |
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playing an important role in cancer progression |
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phosphorylates FOXO transcription factors in the cytosol and histone H2B in the nucleus to promote cellular apoptosis |
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plays crucial roles in lymphocyte trafficking |
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key enzyme involved in lymphocyte entry and interstitial migration |
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phosphorylating TNNI3 in the heart and may contribute to the modulation of myofilament function |
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serine/threonine kinase that is cleaved and activated by caspases during apoptosis, and induces apoptotic chromatin condensation through its phosphorylation of histone H2FAX at Ser-139 |
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caspase-mediated cleavage is responsible for the phosphorylation of H2FAX |
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stimulates transcription of the proapoptotic mediator PMAIP1 in a FOXO1-dependent manner |
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STK3, STK4 control Rho GTPase activation and the migratory responses of single-positive (SP) thymocytes |
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hydrogen peroxide-stimulated STK4 activates a positive feedback loop to sustain an oxidizing cellular state |
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STK3/STK4 are required for proper cardiac lineage cell development and teratoma formation |
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STK3, STK4 are key players in mammalian Hippo pathway |
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STK3/STK4 regulate potentially placental development by control of trophoblast cell differentiation and labyrinthine vasculature at midgestation and STK3/STK4 control labyrinth morphogenesis in trophoblast- and fetal endothelial-dependent manners |