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FLASH GENE

Symbol

HOXB13

contributors: mct/npt/pgu - updated : 22-04-2010

HGNC name	homeobox B13
HGNC id	5112

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in endometrial, ovarian, and cervical carcinomas and is associated with the invasiveness of ovarian and endometrial cancer cells tumoral     --low   by hypermethylation of HOXB13 is a late event of breast tumorigenesis and a poor prognostic indicator of node-positive cancer patients

Susceptibility

to hereditary prostate cancer

Variant & Polymorphism other	HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS