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FLASH GENE
Symbol HOXB13 contributors: mct/npt/pgu - updated : 22-04-2010
HGNC name homeobox B13
HGNC id 5112
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix DNA binding domain
    • HOMOLOGY
    interspecies homolog to murine Hoxb13
    Homologene
    FAMILY
  • ABD-B homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in fetal skin development and cutaneous regeneration
  • may play an important role in tumors arising from endocrine-responsive organs
  • functions as an AR repressor to modulate the complex AR signaling and subsequent growth regulation of prostate cancer cells
  • with the androgen receptor (AR), plays a critical role in the normal development of the prostate gland
  • homeobox transcription factor gene that is important in prostate development
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the DNA-binding domain of AR and inhibits the transcription of genes that contain an androgen-response element (ARE)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in endometrial, ovarian, and cervical carcinomas and is associated with the invasiveness of ovarian and endometrial cancer cells
    tumoral     --low  
    by hypermethylation of HOXB13 is a late event of breast tumorigenesis and a poor prognostic indicator of node-positive cancer patients
    Susceptibility to hereditary prostate cancer
    Variant & Polymorphism other
  • HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS