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FLASH GENE

Symbol

TARBP2

contributors: shn/mct - updated : 28-12-2015

HGNC name	TAR (HIV-1) RNA binding protein 2
HGNC id	11569

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in mesothelioma tumoral     --over   in endometrial cancer metastasis tumoral somatic mutation     loss of function truncating mutations in tumors with microsatellite instability causing diminished TRBP protein expression and defective processing of miRNAs (Melo 2009) tumoral     --over   in many cancers such as prostate cancer, cutaneous malignant melanoma, and adrenocortical carcinoma tumoral     --low   in some cancers including colorectal cancer, gastric cancer, Ewing sarcoma, and upper urinary tract urothelial carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	breast cancer patients with TARBP2 cytoplasm expression have unfavorable prognosis, and patients of triple-negative breast cancer (TNBC) and late-stage breast cancer with higher cytoplasm TARBP2 expression have an unfavorable prognosis
Therapy target

ANIMAL & CELL MODELS

mice homozygous for the mutant Prkra allele had defects not only in ear development but also growth, craniofacial development and ovarian structure