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FLASH GENE
Symbol SRP14 contributors: mct/npt - updated : 13-03-2010
HGNC name signal recognition particle 14kDa (homologous Alu RNA binding protein)
HGNC id 11299
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • alanine-rich C terminal domain
    • conjugated RiboP
    mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans F25G6.8
    Homologene
    FAMILY
  • SRP family of GTP binding proteins
    • CATEGORY RNA associated , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • involved in targeting secretory and membrane proteins to the rough endoplasmic reticulum membrane
  • SRP9/14 subunit of the signal recognition particle binds to a variety of Alu-like RNAs (Bovia 1997)
  • recognizes signal sequences of nascent protein chains emerging from the ribosome (Halic 2004)
  • essential for targeting nascent chains to the endoplasmic reticulum, and it delays nascent chain elongation in cell-free translation systems (Lakkaraju 2008)
    • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming with SRP9 and SRPRNA the elongation arrest domain of SRP
  • subunit of the signal recognition particle (SRP) which is a ribonucleoprotein complex (SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9)
    • INTERACTION
    DNA
    RNA required with SRP9 for binding to the Alu homologous region of 7S RNA
    small molecule
    protein
  • SRPR
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS