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FLASH GENE
Symbol SRP14 contributors: mct/npt - updated : 13-03-2010
HGNC name signal recognition particle 14kDa (homologous Alu RNA binding protein)
HGNC id 11299
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • alanine-rich C terminal domain
    • conjugated RiboP
    mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans F25G6.8
    Homologene
    FAMILY
  • SRP family of GTP binding proteins
    • CATEGORY RNA associated , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • involved in targeting secretory and membrane proteins to the rough endoplasmic reticulum membrane
  • SRP9/14 subunit of the signal recognition particle binds to a variety of Alu-like RNAs (Bovia 1997)
  • recognizes signal sequences of nascent protein chains emerging from the ribosome (Halic 2004)
  • essential for targeting nascent chains to the endoplasmic reticulum, and it delays nascent chain elongation in cell-free translation systems (Lakkaraju 2008)
    • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming with SRP9 and SRPRNA the elongation arrest domain of SRP
  • subunit of the signal recognition particle (SRP) which is a ribonucleoprotein complex (SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9)
    • INTERACTION
    DNA
    RNA required with SRP9 for binding to the Alu homologous region of 7S RNA
    small molecule
    protein
  • SRPR
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS